Authors
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Abdulsalam, G. T.
Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Author
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Isah, A. B.
Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Author
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Bhatia, P. G.
Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria, Nigeria.
Author
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Mohammad, B. B.
Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Author
Keywords:
Enzyme-hydrolyzed starch, Microcrystalline starch, Direct compression, α-amylase.
Abstract
Purpose: To investigate the tableting properties of Enzyme-Hydrolyzed Cassava Starch (EHS)
used as a direct compression excipient in the formulation of Chloroquine Phosphate tablet and to
compare it to the properties of tablets produced using Microcrystalline Cellulose (MCC)
Methods: Enzyme-hydrolyzed cassava starch (EHS) was produced by enzymatic hydrolysis of
Native Cassava starch using α-amylase. The hydrolysis was allowed to proceed for 6h under
optimum temperature and pH. The derived EHS was recovered by filtration after precipitation with
ethanol (95 %v/v). The Powder properties were investigated and tablets of Chloroquine Phosphate
were formulated using EHS and MCC as binary binders at different ratio of 0:100, 25:75, 50:50,
75:25 and 100:0.
Results: The tablets were evaluated and the crushing strength of the tablets was found to increase
in binary mixture of MCC while Friability increased with increase in the proportion of EHS. The
disintegration time was above 60 min, tablets continued to swell, absorbing more water without
disintegrating for the period of the study.
Conclusion: Enzyme hydrolyzed starch may not be suitable for use as a direct compression
excipient in the production of chloroquine tablet.
Author Biographies
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Abdulsalam, G. T., Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Lecturer in the Department of Pharmaceutics and Industrial Pharmacy at Kaduna State University. Her research focuses on the modification of natural polymers and starches for use as functional excipients in direct compression and specialized drug delivery systems.
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Isah, A. B., Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Academic researcher at Kaduna State University who contributed to the study design and the evaluation of the powder properties and compactibility of enzyme-hydrolyzed starches.
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Bhatia, P. G., Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria, Nigeria.
Specialist in pharmaceutical technology at Ahmadu Bello University. He provided technical oversight for the enzymatic hydrolysis process and the comparative analysis of binary binder ratios in tablet formulation.
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Mohammad, B. B., Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.
Researcher at Kaduna State University involved in the laboratory characterization of tablet mechanical strength, including crushing strength and friability tests of the chloroquine formulations.
